Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Testicular morphology and seminal fluid parameters of adult Wistar rats following honey administration

Eniola R Kadir¹ , Lekan S Ojulari², Abdulmumin Ibrahim¹, Oluwole J Ekundayo¹, Rukayat Jaji-Sulaimon¹, Hidaayah Jimoh-Abdulghaffaar²

¹Department of Anatomy; ²Department of Physiology, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria.

For correspondence:- Eniola Kadir Email: ennyshittabey@yahoo.com Tel:+2348023550366

Accepted: 26 March 2018 Published: 28 July 2018

Citation: Kadir ER, Ojulari LS, Ibrahim A, Ekundayo OJ, Jaji-Sulaimon R, Jimoh-Abdulghaffaar H. Testicular morphology and seminal fluid parameters of adult Wistar rats following honey administration. Trop J Pharm Res 2018; 17(7):1331-1335 doi: Honey, Fertility, Spermatozo

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: Honey has a long history of use in the traditional medical systems This objective of this study was to find out the effects of honey on quality and quantity of sperm and testicular microstructure when compared to fertility boosting drug and controls.

Methods: A total number of thirty (30) matured male Wistar rats that were sexually active weighing 200 - 280g were used for this study. The animals were grouped into five as A - E. Group A was the control; Group B (standard group) was the standard group that received 0.3ml of follicle stimulating hormone (FSH) drug for 6 days; groups C, D and E received 1ml, 2ml, and 2.5ml of honey daily for 21days respectively. After 21 days of administration, the testes were removed for analysis of the sperm parameters and the histology.

Results: Honey significantly improved the sperm quality and spermatogenesis rate (denser seminiferous tubule lumen) of exposed animals compared to control animals, but most improvement was seen in the standard group that received 0.3ml FSH. Also no sign of degeneration or cellular loss was observable in the testicular histo-architecture of experimental animals.

Conclusion: This research showed that honey possesses some fertility boosting properties in exposed animals compared to controls and honey is not associated with increased sperm abnormalities.

Keywords: Honey, Fertility, Spermatozoa, Ologospermai